Effects of Nicotine Exposure From Tobacco Products and Electronic Cigarettes on the Pathogenesis of Neurological Diseases: Impact on CNS Drug Delivery

Nicotine, the major component of tobacco smoke (TS) and electronic cigarette (e-cig) vape, has been reported in some cases to be prodromal cerebrovascular toxicity as well a promoting factor for onset various neurological diseases. In conditions, pre-exposure nicotine can lead state compromised blood-brain barrier (BBB) integrity, including altered BBB-related protein expression, BBB leakage, defective ion glucose homeostasis within brain. Moreover, drugs used treat central nervous system disorders (CNS) have interact with other components TS/e-cig through both transporter enzyme-based mechanisms. Herein we discuss nicotine’s potential at brain cerebrovasculature explain how (from smoking/vaping) may interfere uptake CNS drug interaction perspective.